A Different TIPE of Immune Homeostasis
نویسندگان
چکیده
Proteins with death effector domains (DED) are key signal transducers involved in cell death and inflammation. In this issue of Cell, Sun et al. (2008) describe TIPE2, a DED protein that negatively regulates both T cell receptor and Toll-like receptor signaling. These findings reveal a new element critical to the maintenance of homeostasis in both the adaptive and innate immune systems.
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عنوان ژورنال:
- Cell
دوره 133 شماره
صفحات -
تاریخ انتشار 2008